Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer

Minnelide/Triptolide (TL) has recently emerged as a potent anticancer drug in non-small cell lung cancer (NSCLC). However, the precise mechanism of its action remains ambiguous. In this study, we elucidated the molecular basis for TL-induced cell death in context to p53 status. Cell death was attrib...

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Detalles Bibliográficos
Autores principales: Kumar, Ajay, Corey, Catherine, Scott, Iain, Shiva, Sruti, D’Cunha, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976872/
https://www.ncbi.nlm.nih.gov/pubmed/27501149
http://dx.doi.org/10.1371/journal.pone.0160783

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