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Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City
BACKGROUND: Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. OBJECTIVE: We aimed to assess the relationship between air pollution and preterm birth using 2008–2010 New York City (NYC) birth certificates linked t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977049/ https://www.ncbi.nlm.nih.gov/pubmed/26862865 http://dx.doi.org/10.1289/ehp.1510266 |
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author | Johnson, Sarah Bobb, Jennifer F. Ito, Kazuhiko Savitz, David A. Elston, Beth Shmool, Jessie L.C. Dominici, Francesca Ross, Zev Clougherty, Jane E. Matte, Thomas |
author_facet | Johnson, Sarah Bobb, Jennifer F. Ito, Kazuhiko Savitz, David A. Elston, Beth Shmool, Jessie L.C. Dominici, Francesca Ross, Zev Clougherty, Jane E. Matte, Thomas |
author_sort | Johnson, Sarah |
collection | PubMed |
description | BACKGROUND: Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. OBJECTIVE: We aimed to assess the relationship between air pollution and preterm birth using 2008–2010 New York City (NYC) birth certificates linked to hospital records. METHODS: We analyzed 258,294 singleton births with 22–42 completed weeks gestation to nonsmoking mothers. Exposures to ambient fine particles (PM2.5) and nitrogen dioxide (NO2) during the first, second, and cumulative third trimesters within 300 m of maternal address were estimated using data from the NYC Community Air Survey and regulatory monitors. We estimated the odds ratio (OR) of spontaneous preterm (gestation < 37 weeks) births for the first- and second-trimester exposures in a logistic mixed model, and the third-trimester cumulative exposures in a discrete time survival model, adjusting for maternal characteristics and delivery hospital. Spatial and temporal components of estimated exposures were also separately analyzed. RESULTS: PM2.5 was not significantly associated with spontaneous preterm birth. NO2 in the second trimester was negatively associated with spontaneous preterm birth in the adjusted model (OR = 0.90; 95% CI: 0.83, 0.97 per 20 ppb). Neither pollutant was significantly associated with spontaneous preterm birth based on adjusted models of temporal exposures, whereas the spatial exposures showed significantly reduced odds ratios (OR = 0.80; 95% CI: 0.67, 0.96 per 10 μg/m3 PM2.5 and 0.88; 95% CI: 0.79, 0.98 per 20 ppb NO2). Without adjustment for hospital, these negative associations were stronger. CONCLUSION: Neither PM2.5 nor NO2 was positively associated with spontaneous preterm delivery in NYC. Delivery hospital was an important spatial confounder. CITATION: Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, Dominici F, Ross Z, Clougherty JE, Matte T. 2016. Ambient fine particulate matter, nitrogen dioxide, and preterm birth in New York City. Environ Health Perspect 124:1283–1290; http://dx.doi.org/10.1289/ehp.1510266 |
format | Online Article Text |
id | pubmed-4977049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-49770492016-08-22 Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City Johnson, Sarah Bobb, Jennifer F. Ito, Kazuhiko Savitz, David A. Elston, Beth Shmool, Jessie L.C. Dominici, Francesca Ross, Zev Clougherty, Jane E. Matte, Thomas Environ Health Perspect Children's Health BACKGROUND: Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. OBJECTIVE: We aimed to assess the relationship between air pollution and preterm birth using 2008–2010 New York City (NYC) birth certificates linked to hospital records. METHODS: We analyzed 258,294 singleton births with 22–42 completed weeks gestation to nonsmoking mothers. Exposures to ambient fine particles (PM2.5) and nitrogen dioxide (NO2) during the first, second, and cumulative third trimesters within 300 m of maternal address were estimated using data from the NYC Community Air Survey and regulatory monitors. We estimated the odds ratio (OR) of spontaneous preterm (gestation < 37 weeks) births for the first- and second-trimester exposures in a logistic mixed model, and the third-trimester cumulative exposures in a discrete time survival model, adjusting for maternal characteristics and delivery hospital. Spatial and temporal components of estimated exposures were also separately analyzed. RESULTS: PM2.5 was not significantly associated with spontaneous preterm birth. NO2 in the second trimester was negatively associated with spontaneous preterm birth in the adjusted model (OR = 0.90; 95% CI: 0.83, 0.97 per 20 ppb). Neither pollutant was significantly associated with spontaneous preterm birth based on adjusted models of temporal exposures, whereas the spatial exposures showed significantly reduced odds ratios (OR = 0.80; 95% CI: 0.67, 0.96 per 10 μg/m3 PM2.5 and 0.88; 95% CI: 0.79, 0.98 per 20 ppb NO2). Without adjustment for hospital, these negative associations were stronger. CONCLUSION: Neither PM2.5 nor NO2 was positively associated with spontaneous preterm delivery in NYC. Delivery hospital was an important spatial confounder. CITATION: Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, Dominici F, Ross Z, Clougherty JE, Matte T. 2016. Ambient fine particulate matter, nitrogen dioxide, and preterm birth in New York City. Environ Health Perspect 124:1283–1290; http://dx.doi.org/10.1289/ehp.1510266 National Institute of Environmental Health Sciences 2016-02-05 2016-08 /pmc/articles/PMC4977049/ /pubmed/26862865 http://dx.doi.org/10.1289/ehp.1510266 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Children's Health Johnson, Sarah Bobb, Jennifer F. Ito, Kazuhiko Savitz, David A. Elston, Beth Shmool, Jessie L.C. Dominici, Francesca Ross, Zev Clougherty, Jane E. Matte, Thomas Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City |
title | Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City |
title_full | Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City |
title_fullStr | Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City |
title_full_unstemmed | Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City |
title_short | Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City |
title_sort | ambient fine particulate matter, nitrogen dioxide, and preterm birth in new york city |
topic | Children's Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977049/ https://www.ncbi.nlm.nih.gov/pubmed/26862865 http://dx.doi.org/10.1289/ehp.1510266 |
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