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Established and New Mouse Models Reveal E2f1 and Cdk2 Dependency of Retinoblastoma and Expose Strategies to Block Tumor Initiation

RB (+/−) individuals develop retinoblastoma and, subsequently, many other tumors. The Rb relatives p107 and p130 protect the tumor-resistant Rb(−/−) mouse retina. Determining the mechanism underlying this tumor suppressor function may expose novel strategies to block Rb-pathway cancers. p107/p130 ar...

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Detalles Bibliográficos
Autores principales:	Sangwan, Monika, McCurdy, Sean R., Livne-bar, Izzy, Ahmad, Mohammad, Wrana, Jeffery L., Chen, Danian, Bremner, Rod
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977187/ https://www.ncbi.nlm.nih.gov/pubmed/22286767 http://dx.doi.org/10.1038/onc.2011.654

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