Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis

Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene have been shown to cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS). A major pathological hallmark of this disease is abnormal accumulation of mutant SOD1 oligomers in the affected spinal motor neurons. While no effective...

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Detalles Bibliográficos
Autores principales: Anzai, Itsuki, Toichi, Keisuke, Tokuda, Eiichi, Mukaiyama, Atsushi, Akiyama, Shuji, Furukawa, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977284/
https://www.ncbi.nlm.nih.gov/pubmed/27556028
http://dx.doi.org/10.3389/fmolb.2016.00040

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