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Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins

Proper function of the nervous system critically relies on sophisticated neuronal networks interconnected in a highly specific pattern. The architecture of these connections arises from sequential developmental steps such as axonal growth and guidance, dendrite development, target determination, syn...

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Detalles Bibliográficos
Autores principales: Ledda, Fernanda, Paratcha, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977320/
https://www.ncbi.nlm.nih.gov/pubmed/27555809
http://dx.doi.org/10.3389/fncel.2016.00199
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author Ledda, Fernanda
Paratcha, Gustavo
author_facet Ledda, Fernanda
Paratcha, Gustavo
author_sort Ledda, Fernanda
collection PubMed
description Proper function of the nervous system critically relies on sophisticated neuronal networks interconnected in a highly specific pattern. The architecture of these connections arises from sequential developmental steps such as axonal growth and guidance, dendrite development, target determination, synapse formation and plasticity. Leucine-rich repeat (LRR) transmembrane proteins have been involved in cell-type specific signaling pathways that underlie these developmental processes. The members of this superfamily of proteins execute their functions acting as trans-synaptic cell adhesion molecules involved in target specificity and synapse formation or working in cis as cell-intrinsic modulators of neurotrophic factor receptor trafficking and signaling. In this review, we will focus on novel physiological mechanisms through which LRR proteins regulate neurotrophic factor receptor signaling, highlighting the importance of these modulatory events for proper axonal extension and guidance, tissue innervation and dendrite morphogenesis. Additionally, we discuss few examples linking this set of LRR proteins to neurodevelopmental and psychiatric disorders.
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spelling pubmed-49773202016-08-23 Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins Ledda, Fernanda Paratcha, Gustavo Front Cell Neurosci Neuroscience Proper function of the nervous system critically relies on sophisticated neuronal networks interconnected in a highly specific pattern. The architecture of these connections arises from sequential developmental steps such as axonal growth and guidance, dendrite development, target determination, synapse formation and plasticity. Leucine-rich repeat (LRR) transmembrane proteins have been involved in cell-type specific signaling pathways that underlie these developmental processes. The members of this superfamily of proteins execute their functions acting as trans-synaptic cell adhesion molecules involved in target specificity and synapse formation or working in cis as cell-intrinsic modulators of neurotrophic factor receptor trafficking and signaling. In this review, we will focus on novel physiological mechanisms through which LRR proteins regulate neurotrophic factor receptor signaling, highlighting the importance of these modulatory events for proper axonal extension and guidance, tissue innervation and dendrite morphogenesis. Additionally, we discuss few examples linking this set of LRR proteins to neurodevelopmental and psychiatric disorders. Frontiers Media S.A. 2016-08-09 /pmc/articles/PMC4977320/ /pubmed/27555809 http://dx.doi.org/10.3389/fncel.2016.00199 Text en Copyright © 2016 Ledda and Paratcha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ledda, Fernanda
Paratcha, Gustavo
Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
title Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
title_full Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
title_fullStr Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
title_full_unstemmed Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
title_short Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins
title_sort assembly of neuronal connectivity by neurotrophic factors and leucine-rich repeat proteins
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977320/
https://www.ncbi.nlm.nih.gov/pubmed/27555809
http://dx.doi.org/10.3389/fncel.2016.00199
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