Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression

Antidepressants increase hippocampal neurogenesis by activating the glucocorticoid receptor (GR), but excessive GR activation impairs hippocampal neurogenesis, suggesting that normal GR function is crucial for hippocampal neurogenesis. Baicalin was reported to regulate the expression of GR and facil...

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Detalles Bibliográficos
Autores principales: Zhang, Kuo, Pan, Xing, Wang, Fang, Ma, Jie, Su, Guangyue, Dong, Yingxu, Yang, Jingyu, Wu, Chunfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977505/
https://www.ncbi.nlm.nih.gov/pubmed/27502757
http://dx.doi.org/10.1038/srep30951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977505/
https://www.ncbi.nlm.nih.gov/pubmed/27502757
http://dx.doi.org/10.1038/srep30951

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