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Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials

Emerging evidence suggests that assisted hatching (AH) techniques may improve clinical pregnancy rates, particularly in poor prognosis patients; however, there still remains considerable uncertainty. We conducted a meta-analysis to verify the effect of AH on pregnancy outcomes. We searched for relat...

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Autores principales: Li, Da, Yang, Da-Lei, An, Jing, Jiao, Jiao, Zhou, Yi-Ming, Wu, Qi-Jun, Wang, Xiu-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977517/
https://www.ncbi.nlm.nih.gov/pubmed/27503701
http://dx.doi.org/10.1038/srep31228
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author Li, Da
Yang, Da-Lei
An, Jing
Jiao, Jiao
Zhou, Yi-Ming
Wu, Qi-Jun
Wang, Xiu-Xia
author_facet Li, Da
Yang, Da-Lei
An, Jing
Jiao, Jiao
Zhou, Yi-Ming
Wu, Qi-Jun
Wang, Xiu-Xia
author_sort Li, Da
collection PubMed
description Emerging evidence suggests that assisted hatching (AH) techniques may improve clinical pregnancy rates, particularly in poor prognosis patients; however, there still remains considerable uncertainty. We conducted a meta-analysis to verify the effect of AH on pregnancy outcomes. We searched for related studies published in PubMed, Web of Science, and Cochrane library databases from start dates to October 10, 2015. Totally, 36 randomized controlled trials with 6459 participants were included. Summary odds ratios (ORs) with 95% confidence intervals (CIs) for whether by AH or not were estimated. We found a significant increase in clinical pregnancy (OR = 1.16, 95% CI = 1.00–1.36, I(2) = 48.3%) and multiple pregnancy rates (OR = 1.50, 95% CI = 1.11–2.01, I(2) = 44.0%) with AH when compared to the control. Numerous subgroup analyses stratified by hatching method, conception mode, extent of AH, embryos transfer status, and previous failure history were also carried out. Interestingly, significant results of clinical pregnancy as well as multiple pregnancy rates were observed among women who received intracytoplasmic sperm injection, and who received AH which the zona were completely removed. In summary, this meta-analysis supports that AH was associated with an increased chance of achieving clinical pregnancy and multiple pregnancy. Whether AH significantly changes live birth and miscarriage rates needs further investigations.
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spelling pubmed-49775172016-08-22 Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials Li, Da Yang, Da-Lei An, Jing Jiao, Jiao Zhou, Yi-Ming Wu, Qi-Jun Wang, Xiu-Xia Sci Rep Article Emerging evidence suggests that assisted hatching (AH) techniques may improve clinical pregnancy rates, particularly in poor prognosis patients; however, there still remains considerable uncertainty. We conducted a meta-analysis to verify the effect of AH on pregnancy outcomes. We searched for related studies published in PubMed, Web of Science, and Cochrane library databases from start dates to October 10, 2015. Totally, 36 randomized controlled trials with 6459 participants were included. Summary odds ratios (ORs) with 95% confidence intervals (CIs) for whether by AH or not were estimated. We found a significant increase in clinical pregnancy (OR = 1.16, 95% CI = 1.00–1.36, I(2) = 48.3%) and multiple pregnancy rates (OR = 1.50, 95% CI = 1.11–2.01, I(2) = 44.0%) with AH when compared to the control. Numerous subgroup analyses stratified by hatching method, conception mode, extent of AH, embryos transfer status, and previous failure history were also carried out. Interestingly, significant results of clinical pregnancy as well as multiple pregnancy rates were observed among women who received intracytoplasmic sperm injection, and who received AH which the zona were completely removed. In summary, this meta-analysis supports that AH was associated with an increased chance of achieving clinical pregnancy and multiple pregnancy. Whether AH significantly changes live birth and miscarriage rates needs further investigations. Nature Publishing Group 2016-08-09 /pmc/articles/PMC4977517/ /pubmed/27503701 http://dx.doi.org/10.1038/srep31228 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Da
Yang, Da-Lei
An, Jing
Jiao, Jiao
Zhou, Yi-Ming
Wu, Qi-Jun
Wang, Xiu-Xia
Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
title Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
title_full Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
title_fullStr Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
title_full_unstemmed Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
title_short Effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
title_sort effect of assisted hatching on pregnancy outcomes: a systematic review and meta-analysis of randomized controlled trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977517/
https://www.ncbi.nlm.nih.gov/pubmed/27503701
http://dx.doi.org/10.1038/srep31228
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