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Identification of IL6 as a susceptibility gene for major depressive disorder

Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed a comprehensive genetic study to determine the association between the gene encoding IL6 (IL6) and MDD in Han Chinese. There were 50 drug-naïve MDD patients...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Wu, Zhiguo, Zhao, Guoqing, Wang, Fan, Fang, Yiru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977523/
https://www.ncbi.nlm.nih.gov/pubmed/27502736
http://dx.doi.org/10.1038/srep31264
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author Zhang, Chen
Wu, Zhiguo
Zhao, Guoqing
Wang, Fan
Fang, Yiru
author_facet Zhang, Chen
Wu, Zhiguo
Zhao, Guoqing
Wang, Fan
Fang, Yiru
author_sort Zhang, Chen
collection PubMed
description Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed a comprehensive genetic study to determine the association between the gene encoding IL6 (IL6) and MDD in Han Chinese. There were 50 drug-naïve MDD patients and 50 healthy controls undergoing an mRNA expression study. A sample of 772 patients with MDD and 759 healthy controls were used for genetic analysis. Next, we performed an eQTL analysis to identify whether risk SNP(s) is associated with IL6 expression in brain. Our results showed that patients with MDD have higher levels of IL6 than healthy controls (P = 0.008). The SNP rs1800797 has a significant association with MDD (P = 0.01) in a dominant model. The eQTL analysis showed a marginally significant association between the rs1800797 and IL6 expression in the frontal cortex (P = 0.087). Our preliminary findings are suggestive of an association between rs1800797 and the risk of MDD. Further investigations are required to evaluate this association in larger samples to increase statistical power, and to examine the correlation between rs1800797 and IL6 methylation patterns.
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spelling pubmed-49775232016-08-22 Identification of IL6 as a susceptibility gene for major depressive disorder Zhang, Chen Wu, Zhiguo Zhao, Guoqing Wang, Fan Fang, Yiru Sci Rep Article Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed a comprehensive genetic study to determine the association between the gene encoding IL6 (IL6) and MDD in Han Chinese. There were 50 drug-naïve MDD patients and 50 healthy controls undergoing an mRNA expression study. A sample of 772 patients with MDD and 759 healthy controls were used for genetic analysis. Next, we performed an eQTL analysis to identify whether risk SNP(s) is associated with IL6 expression in brain. Our results showed that patients with MDD have higher levels of IL6 than healthy controls (P = 0.008). The SNP rs1800797 has a significant association with MDD (P = 0.01) in a dominant model. The eQTL analysis showed a marginally significant association between the rs1800797 and IL6 expression in the frontal cortex (P = 0.087). Our preliminary findings are suggestive of an association between rs1800797 and the risk of MDD. Further investigations are required to evaluate this association in larger samples to increase statistical power, and to examine the correlation between rs1800797 and IL6 methylation patterns. Nature Publishing Group 2016-08-09 /pmc/articles/PMC4977523/ /pubmed/27502736 http://dx.doi.org/10.1038/srep31264 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Chen
Wu, Zhiguo
Zhao, Guoqing
Wang, Fan
Fang, Yiru
Identification of IL6 as a susceptibility gene for major depressive disorder
title Identification of IL6 as a susceptibility gene for major depressive disorder
title_full Identification of IL6 as a susceptibility gene for major depressive disorder
title_fullStr Identification of IL6 as a susceptibility gene for major depressive disorder
title_full_unstemmed Identification of IL6 as a susceptibility gene for major depressive disorder
title_short Identification of IL6 as a susceptibility gene for major depressive disorder
title_sort identification of il6 as a susceptibility gene for major depressive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977523/
https://www.ncbi.nlm.nih.gov/pubmed/27502736
http://dx.doi.org/10.1038/srep31264
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