Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues

The Mycobacterium tuberculosis dihydrodipicolinate synthase (Mtb-dapA) is an essential gene. Mtb-DapA catalyzes the aldol condensation between pyruvate and L-aspartate-beta-semialdehyde (ASA) to yield dihydrodipicolinate. In this work we tested the inhibitory effects of structural analogues of pyruv...

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Detalles Bibliográficos
Autores principales: Shrivastava, Priyanka, Navratna, Vikas, Silla, Yumnam, Dewangan, Rikeshwer P., Pramanik, Atreyi, Chaudhary, Sarika, Rayasam, GeethaVani, Kumar, Anuradha, Gopal, Balasubramanian, Ramachandran, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977564/
https://www.ncbi.nlm.nih.gov/pubmed/27501775
http://dx.doi.org/10.1038/srep30827

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