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Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs

Cough remains a major unmet clinical need, and preclinical animal models are not predictive for new antitussive agents. We have investigated the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses in rabbits and guinea pigs. Ozone induced a significant increase in coug...

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Detalles Bibliográficos
Autores principales:	Clay, Emlyn, Patacchini, Riccardo, Trevisani, Marcello, Preti, Delia, Branà, Maria Pia, Spina, Domenico, Page, Clive
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:	Gastrointestinal, Hepatic, Pulmonary, and Renal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977573/ https://www.ncbi.nlm.nih.gov/pubmed/26837703 http://dx.doi.org/10.1124/jpet.115.230227

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