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Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but pro...

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Detalles Bibliográficos
Autores principales:	Bridges, Hannah R., Sirviö, Ville A., Agip, Ahmed-Noor A., Hirst, Judy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977651/ https://www.ncbi.nlm.nih.gov/pubmed/27506389 http://dx.doi.org/10.1186/s12915-016-0287-9

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