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Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population

OBJECTIVE: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. METHODS: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their...

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Autores principales: Yücel, Yavuz, Coşkun, Salih, Cengiz, Beyhan, Özdemir, Hasan H., Uzar, Ertuğrul, Çim, Abdullah, Camkurt, M. Akif, Aluclu, M. Ufuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977812/
https://www.ncbi.nlm.nih.gov/pubmed/27489378
http://dx.doi.org/10.9758/cpn.2016.14.3.250
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author Yücel, Yavuz
Coşkun, Salih
Cengiz, Beyhan
Özdemir, Hasan H.
Uzar, Ertuğrul
Çim, Abdullah
Camkurt, M. Akif
Aluclu, M. Ufuk
author_facet Yücel, Yavuz
Coşkun, Salih
Cengiz, Beyhan
Özdemir, Hasan H.
Uzar, Ertuğrul
Çim, Abdullah
Camkurt, M. Akif
Aluclu, M. Ufuk
author_sort Yücel, Yavuz
collection PubMed
description OBJECTIVE: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. METHODS: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (−759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. RESULTS: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. CONCLUSION: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
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spelling pubmed-49778122016-08-09 Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population Yücel, Yavuz Coşkun, Salih Cengiz, Beyhan Özdemir, Hasan H. Uzar, Ertuğrul Çim, Abdullah Camkurt, M. Akif Aluclu, M. Ufuk Clin Psychopharmacol Neurosci Original Article OBJECTIVE: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. METHODS: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (−759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. RESULTS: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. CONCLUSION: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population. Korean College of Neuropsychopharmacology 2016-08 2016-08-31 /pmc/articles/PMC4977812/ /pubmed/27489378 http://dx.doi.org/10.9758/cpn.2016.14.3.250 Text en Copyright © 2016, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yücel, Yavuz
Coşkun, Salih
Cengiz, Beyhan
Özdemir, Hasan H.
Uzar, Ertuğrul
Çim, Abdullah
Camkurt, M. Akif
Aluclu, M. Ufuk
Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
title Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
title_full Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
title_fullStr Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
title_full_unstemmed Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
title_short Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
title_sort association of polymorphisms within the serotonin receptor genes 5-htr1a, 5-htr1b, 5-htr2a and 5-htr2c and migraine susceptibility in a turkish population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977812/
https://www.ncbi.nlm.nih.gov/pubmed/27489378
http://dx.doi.org/10.9758/cpn.2016.14.3.250
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