Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

BACKGROUND: Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of loss of Fragile X Mental Retardation Protein (FMRP), but recent work has shown...

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Detalles Bibliográficos
Autores principales: Truszkowski, Torrey L. S., James, Eric J., Hasan, Mashfiq, Wishard, Tyler J., Liu, Zhenyu, Pratt, Kara G., Cline, Hollis T., Aizenman, Carlos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977860/
https://www.ncbi.nlm.nih.gov/pubmed/27503008
http://dx.doi.org/10.1186/s13064-016-0069-7

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