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Brain abscess caused by Nocardia asiatica

BACKGROUND: Nocardia infection of the central nervous system leading to brain abscess is a rare condition but has a high mortality rate. Among the species of Nocardia, only three cases of brain abscess due to Nocardia asiatica infection have been reported. CASE DESCRIPTION: A 65-year-old man with a...

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Autores principales: Uneda, Atsuhito, Suzuki, Kenta, Okubo, Shuichi, Hirashita, Koji, Yunoki, Masatoshi, Yoshino, Kimihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977971/
https://www.ncbi.nlm.nih.gov/pubmed/27563485
http://dx.doi.org/10.4103/2152-7806.186509
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author Uneda, Atsuhito
Suzuki, Kenta
Okubo, Shuichi
Hirashita, Koji
Yunoki, Masatoshi
Yoshino, Kimihiro
author_facet Uneda, Atsuhito
Suzuki, Kenta
Okubo, Shuichi
Hirashita, Koji
Yunoki, Masatoshi
Yoshino, Kimihiro
author_sort Uneda, Atsuhito
collection PubMed
description BACKGROUND: Nocardia infection of the central nervous system leading to brain abscess is a rare condition but has a high mortality rate. Among the species of Nocardia, only three cases of brain abscess due to Nocardia asiatica infection have been reported. CASE DESCRIPTION: A 65-year-old man with a history of autoimmune hemolytic anemia treated with prednisolone presented to our hospital because of occipital headache. Brain magnetic resonance imaging showed bilateral occipital lesions. The patient underwent craniotomy and resection of the left occipital lobe lesion. N. asiatica was identified by 16S rRNA sequencing of the resected specimen. Treatment with trimethoprim/sulfamethoxazole led to a complete resolution of the brain lesion. CONCLUSION: Because of the different antimicrobial sensitivity patterns among Nocardia species, both appropriate subtyping and susceptibility testing of uncommon species such as N. asiatica are required for the successful treatment of nocardial infections.
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spelling pubmed-49779712016-08-25 Brain abscess caused by Nocardia asiatica Uneda, Atsuhito Suzuki, Kenta Okubo, Shuichi Hirashita, Koji Yunoki, Masatoshi Yoshino, Kimihiro Surg Neurol Int Case Report BACKGROUND: Nocardia infection of the central nervous system leading to brain abscess is a rare condition but has a high mortality rate. Among the species of Nocardia, only three cases of brain abscess due to Nocardia asiatica infection have been reported. CASE DESCRIPTION: A 65-year-old man with a history of autoimmune hemolytic anemia treated with prednisolone presented to our hospital because of occipital headache. Brain magnetic resonance imaging showed bilateral occipital lesions. The patient underwent craniotomy and resection of the left occipital lobe lesion. N. asiatica was identified by 16S rRNA sequencing of the resected specimen. Treatment with trimethoprim/sulfamethoxazole led to a complete resolution of the brain lesion. CONCLUSION: Because of the different antimicrobial sensitivity patterns among Nocardia species, both appropriate subtyping and susceptibility testing of uncommon species such as N. asiatica are required for the successful treatment of nocardial infections. Medknow Publications & Media Pvt Ltd 2016-07-18 /pmc/articles/PMC4977971/ /pubmed/27563485 http://dx.doi.org/10.4103/2152-7806.186509 Text en Copyright: © 2016 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Uneda, Atsuhito
Suzuki, Kenta
Okubo, Shuichi
Hirashita, Koji
Yunoki, Masatoshi
Yoshino, Kimihiro
Brain abscess caused by Nocardia asiatica
title Brain abscess caused by Nocardia asiatica
title_full Brain abscess caused by Nocardia asiatica
title_fullStr Brain abscess caused by Nocardia asiatica
title_full_unstemmed Brain abscess caused by Nocardia asiatica
title_short Brain abscess caused by Nocardia asiatica
title_sort brain abscess caused by nocardia asiatica
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977971/
https://www.ncbi.nlm.nih.gov/pubmed/27563485
http://dx.doi.org/10.4103/2152-7806.186509
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