Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade

BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109...

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Detalles Bibliográficos
Autores principales: Liu, Linghua, Huang, Ruokun, Ma, Dezhang, Cheng, Wenjun, Feng, Wei, Xing, Danmou, Kan, Wusheng, Xiao, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978210/
https://www.ncbi.nlm.nih.gov/pubmed/27495944
http://dx.doi.org/10.12659/MSM.896987
Descripción
Sumario:BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades. CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA.

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