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Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade

BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109...

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Autores principales: Liu, Linghua, Huang, Ruokun, Ma, Dezhang, Cheng, Wenjun, Feng, Wei, Xing, Danmou, Kan, Wusheng, Xiao, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978210/
https://www.ncbi.nlm.nih.gov/pubmed/27495944
http://dx.doi.org/10.12659/MSM.896987
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author Liu, Linghua
Huang, Ruokun
Ma, Dezhang
Cheng, Wenjun
Feng, Wei
Xing, Danmou
Kan, Wusheng
Xiao, Zhihong
author_facet Liu, Linghua
Huang, Ruokun
Ma, Dezhang
Cheng, Wenjun
Feng, Wei
Xing, Danmou
Kan, Wusheng
Xiao, Zhihong
author_sort Liu, Linghua
collection PubMed
description BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades. CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA.
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spelling pubmed-49782102016-08-22 Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade Liu, Linghua Huang, Ruokun Ma, Dezhang Cheng, Wenjun Feng, Wei Xing, Danmou Kan, Wusheng Xiao, Zhihong Med Sci Monit Clinical Research BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades. CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA. International Scientific Literature, Inc. 2016-08-06 /pmc/articles/PMC4978210/ /pubmed/27495944 http://dx.doi.org/10.12659/MSM.896987 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Clinical Research
Liu, Linghua
Huang, Ruokun
Ma, Dezhang
Cheng, Wenjun
Feng, Wei
Xing, Danmou
Kan, Wusheng
Xiao, Zhihong
Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
title Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
title_full Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
title_fullStr Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
title_full_unstemmed Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
title_short Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
title_sort correlation of adrenomedullin concentrations with knee osteoarthritis grade
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978210/
https://www.ncbi.nlm.nih.gov/pubmed/27495944
http://dx.doi.org/10.12659/MSM.896987
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