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Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade
BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978210/ https://www.ncbi.nlm.nih.gov/pubmed/27495944 http://dx.doi.org/10.12659/MSM.896987 |
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author | Liu, Linghua Huang, Ruokun Ma, Dezhang Cheng, Wenjun Feng, Wei Xing, Danmou Kan, Wusheng Xiao, Zhihong |
author_facet | Liu, Linghua Huang, Ruokun Ma, Dezhang Cheng, Wenjun Feng, Wei Xing, Danmou Kan, Wusheng Xiao, Zhihong |
author_sort | Liu, Linghua |
collection | PubMed |
description | BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades. CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA. |
format | Online Article Text |
id | pubmed-4978210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49782102016-08-22 Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade Liu, Linghua Huang, Ruokun Ma, Dezhang Cheng, Wenjun Feng, Wei Xing, Danmou Kan, Wusheng Xiao, Zhihong Med Sci Monit Clinical Research BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL/METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades. CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA. International Scientific Literature, Inc. 2016-08-06 /pmc/articles/PMC4978210/ /pubmed/27495944 http://dx.doi.org/10.12659/MSM.896987 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
spellingShingle | Clinical Research Liu, Linghua Huang, Ruokun Ma, Dezhang Cheng, Wenjun Feng, Wei Xing, Danmou Kan, Wusheng Xiao, Zhihong Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade |
title | Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade |
title_full | Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade |
title_fullStr | Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade |
title_full_unstemmed | Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade |
title_short | Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade |
title_sort | correlation of adrenomedullin concentrations with knee osteoarthritis grade |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978210/ https://www.ncbi.nlm.nih.gov/pubmed/27495944 http://dx.doi.org/10.12659/MSM.896987 |
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