Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis

OBJECTIVE: We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology. METHODS: Del1 KO and WT mice had cartilage thic...

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Detalles Bibliográficos
Autores principales: Wang, Zhen, Tran, Misha C., Bhatia, Namrata J., Hsing, Alexander W., Chen, Carol, LaRussa, Marie F., Fattakhov, Ernst, Rashidi, Vania, Jang, Kyu Yun, Choo, Kevin J., Nie, Xingju, Mathy, Jonathan A., Longaker, Michael T., Dauskardt, Reinhold H., Helms, Jill A., Yang, George P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978450/
https://www.ncbi.nlm.nih.gov/pubmed/27505251
http://dx.doi.org/10.1371/journal.pone.0160684

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