Cargando…

Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis

The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resi...

Descripción completa

Detalles Bibliográficos
Autores principales: Eldholm, Vegard, Rieux, Adrien, Monteserin, Johana, Lopez, Julia Montana, Palmero, Domingo, Lopez, Beatriz, Ritacco, Viviana, Didelot, Xavier, Balloux, Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978521/
https://www.ncbi.nlm.nih.gov/pubmed/27502557
http://dx.doi.org/10.7554/eLife.16644
_version_ 1782447187757629440
author Eldholm, Vegard
Rieux, Adrien
Monteserin, Johana
Lopez, Julia Montana
Palmero, Domingo
Lopez, Beatriz
Ritacco, Viviana
Didelot, Xavier
Balloux, Francois
author_facet Eldholm, Vegard
Rieux, Adrien
Monteserin, Johana
Lopez, Julia Montana
Palmero, Domingo
Lopez, Beatriz
Ritacco, Viviana
Didelot, Xavier
Balloux, Francois
author_sort Eldholm, Vegard
collection PubMed
description The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains. DOI: http://dx.doi.org/10.7554/eLife.16644.001
format Online
Article
Text
id pubmed-4978521
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-49785212016-08-10 Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis Eldholm, Vegard Rieux, Adrien Monteserin, Johana Lopez, Julia Montana Palmero, Domingo Lopez, Beatriz Ritacco, Viviana Didelot, Xavier Balloux, Francois eLife Genomics and Evolutionary Biology The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains. DOI: http://dx.doi.org/10.7554/eLife.16644.001 eLife Sciences Publications, Ltd 2016-08-09 /pmc/articles/PMC4978521/ /pubmed/27502557 http://dx.doi.org/10.7554/eLife.16644 Text en © 2016, Eldholm et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Genomics and Evolutionary Biology
Eldholm, Vegard
Rieux, Adrien
Monteserin, Johana
Lopez, Julia Montana
Palmero, Domingo
Lopez, Beatriz
Ritacco, Viviana
Didelot, Xavier
Balloux, Francois
Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_full Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_fullStr Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_full_unstemmed Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_short Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_sort impact of hiv co-infection on the evolution and transmission of multidrug-resistant tuberculosis
topic Genomics and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978521/
https://www.ncbi.nlm.nih.gov/pubmed/27502557
http://dx.doi.org/10.7554/eLife.16644
work_keys_str_mv AT eldholmvegard impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT rieuxadrien impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT monteserinjohana impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT lopezjuliamontana impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT palmerodomingo impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT lopezbeatriz impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT ritaccoviviana impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT didelotxavier impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis
AT ballouxfrancois impactofhivcoinfectionontheevolutionandtransmissionofmultidrugresistanttuberculosis