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Differences in the emergent coding properties of cortical and striatal ensembles

The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. In the present study, multiple neurons from the anterior cingulate cortex (ACC) and the dorsal s...

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Detalles Bibliográficos
Autores principales: Ma, L., Hyman, J.M., Lindsay, A.J., Phillips, A.G., Seamans, J.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978541/
https://www.ncbi.nlm.nih.gov/pubmed/24974796
http://dx.doi.org/10.1038/nn.3753
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author Ma, L.
Hyman, J.M.
Lindsay, A.J.
Phillips, A.G.
Seamans, J.K.
author_facet Ma, L.
Hyman, J.M.
Lindsay, A.J.
Phillips, A.G.
Seamans, J.K.
author_sort Ma, L.
collection PubMed
description The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. In the present study, multiple neurons from the anterior cingulate cortex (ACC) and the dorsal striatum (DS) were recorded simultaneously as rats performed different sequences of the same three actions. Sequence and lever decoding was remarkably similar on a per-neuron basis in the two regions. At the ensemble level, sequence-specific representations in the DS appeared synchronously but transiently along with the representation of lever location, while these two streams of information appeared independently and asynchronously in the ACC. As a result the ACC achieved superior ensemble decoding accuracy overall. Thus, the manner in which information was combined across neurons in an ensemble determined the functional separation of the ACC and DS on this task.
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spelling pubmed-49785412016-08-09 Differences in the emergent coding properties of cortical and striatal ensembles Ma, L. Hyman, J.M. Lindsay, A.J. Phillips, A.G. Seamans, J.K. Nat Neurosci Article The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. In the present study, multiple neurons from the anterior cingulate cortex (ACC) and the dorsal striatum (DS) were recorded simultaneously as rats performed different sequences of the same three actions. Sequence and lever decoding was remarkably similar on a per-neuron basis in the two regions. At the ensemble level, sequence-specific representations in the DS appeared synchronously but transiently along with the representation of lever location, while these two streams of information appeared independently and asynchronously in the ACC. As a result the ACC achieved superior ensemble decoding accuracy overall. Thus, the manner in which information was combined across neurons in an ensemble determined the functional separation of the ACC and DS on this task. 2014-06-29 2014-08 /pmc/articles/PMC4978541/ /pubmed/24974796 http://dx.doi.org/10.1038/nn.3753 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ma, L.
Hyman, J.M.
Lindsay, A.J.
Phillips, A.G.
Seamans, J.K.
Differences in the emergent coding properties of cortical and striatal ensembles
title Differences in the emergent coding properties of cortical and striatal ensembles
title_full Differences in the emergent coding properties of cortical and striatal ensembles
title_fullStr Differences in the emergent coding properties of cortical and striatal ensembles
title_full_unstemmed Differences in the emergent coding properties of cortical and striatal ensembles
title_short Differences in the emergent coding properties of cortical and striatal ensembles
title_sort differences in the emergent coding properties of cortical and striatal ensembles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978541/
https://www.ncbi.nlm.nih.gov/pubmed/24974796
http://dx.doi.org/10.1038/nn.3753
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