Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions

Due to the GC-rich, repetitive nature of C9orf72 hexanucleotide repeat expansions, PCR based detection methods are challenging. Several limitations of PCR have been reported and overcoming these could help to define the pathogenic range. There is also a need to develop improved repeat-primed PCR ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Cleary, Elaine M., Pal, Suvankar, Azam, Tara, Moore, David J., Swingler, Robert, Gorrie, George, Stephenson, Laura, Colville, Shuna, Chandran, Siddharthan, Porteous, Mary, Warner, Jon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978699/
https://www.ncbi.nlm.nih.gov/pubmed/27288208
http://dx.doi.org/10.1016/j.mcp.2016.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978699/
https://www.ncbi.nlm.nih.gov/pubmed/27288208
http://dx.doi.org/10.1016/j.mcp.2016.06.001

Ejemplares similares