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Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions
Due to the GC-rich, repetitive nature of C9orf72 hexanucleotide repeat expansions, PCR based detection methods are challenging. Several limitations of PCR have been reported and overcoming these could help to define the pathogenic range. There is also a need to develop improved repeat-primed PCR ass...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978699/ https://www.ncbi.nlm.nih.gov/pubmed/27288208 http://dx.doi.org/10.1016/j.mcp.2016.06.001 |