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Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1

SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I interferon (IFN) secretion. We show that the spontaneous IFN response in SAMHD1-deficient cells and mice requires the cGAS/STING cytosoli...

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Detalles Bibliográficos
Autores principales:	Maelfait, Jonathan, Bridgeman, Anne, Benlahrech, Adel, Cursi, Chiara, Rehwinkel, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978700/ https://www.ncbi.nlm.nih.gov/pubmed/27477283 http://dx.doi.org/10.1016/j.celrep.2016.07.002

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