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Identification of Functional Domains in the Cohesin Loader Subunit Scc4 by a Random Insertion/Dominant Negative Screen

Cohesin is a multi-subunit complex that plays an essential role in genome stability. Initial association of cohesin with chromosomes requires the loader—a heterodimer composed of Scc4 and Scc2. However, very little is known about the loader’s mechanism of action. In this study, we performed a geneti...

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Detalles Bibliográficos
Autores principales: Shwartz, Michal, Matityahu, Avi, Onn, Itay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978918/
https://www.ncbi.nlm.nih.gov/pubmed/27280786
http://dx.doi.org/10.1534/g3.116.031674

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