CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets

Summary: Promoter capture Hi-C (PCHi-C) allows the genome-wide interrogation of physical interactions between distal DNA regulatory elements and gene promoters in multiple tissue contexts. Visual integration of the resultant chromosome interaction maps with other sources of genomic annotations can p...

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Detalles Bibliográficos
Autores principales: Schofield, E. C., Carver, T., Achuthan, P., Freire-Pritchett, P., Spivakov, M., Todd, J. A., Burren, O. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978926/
https://www.ncbi.nlm.nih.gov/pubmed/27153610
http://dx.doi.org/10.1093/bioinformatics/btw173
Descripción
Sumario:Summary: Promoter capture Hi-C (PCHi-C) allows the genome-wide interrogation of physical interactions between distal DNA regulatory elements and gene promoters in multiple tissue contexts. Visual integration of the resultant chromosome interaction maps with other sources of genomic annotations can provide insight into underlying regulatory mechanisms. We have developed Capture HiC Plotter (CHiCP), a web-based tool that allows interactive exploration of PCHi-C interaction maps and integration with both public and user-defined genomic datasets. Availability and Implementation: CHiCP is freely accessible from www.chicp.org and supports most major HTML5 compliant web browsers. Full source code and installation instructions are available from http://github.com/D-I-L/django-chicp. Contact: ob219@cam.ac.uk

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