The CD4(+) T cell methylome contributes to a distinct CD4(+) T cell transcriptional signature in Mycobacterium bovis-infected cattle

We hypothesised that epigenetic regulation of CD4(+) T lymphocytes contributes to a shift toward a dysfunctional T cell phenotype which may impact on their ability to clear mycobacterial infection. Combined RNA-seq transcriptomic profiling and Reduced Representation Bisulfite Sequencing identified 1...

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Detalles Bibliográficos
Autores principales: Doherty, Rachael, Whiston, Ronan, Cormican, Paul, Finlay, Emma K., Couldrey, Christine, Brady, Colm, O’Farrelly, Cliona, Meade, Kieran G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978967/
https://www.ncbi.nlm.nih.gov/pubmed/27507428
http://dx.doi.org/10.1038/srep31014

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