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Epidermal growth factor gene is a newly identified candidate gene for gout
Chromosome 4q25 has been identified as a genomic region associated with gout. However, the associations of gout with the genes in this region have not yet been confirmed. Here, we performed two-stage analysis to determine whether variations in candidate genes in the 4q25 region are associated with g...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978989/ https://www.ncbi.nlm.nih.gov/pubmed/27506295 http://dx.doi.org/10.1038/srep31082 |
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author | Han, Lin Cao, Chunwei Jia, Zhaotong Liu, Shiguo Liu, Zhen Xin, Ruosai Wang, Can Li, Xinde Ren, Wei Wang, Xuefeng Li, Changgui |
author_facet | Han, Lin Cao, Chunwei Jia, Zhaotong Liu, Shiguo Liu, Zhen Xin, Ruosai Wang, Can Li, Xinde Ren, Wei Wang, Xuefeng Li, Changgui |
author_sort | Han, Lin |
collection | PubMed |
description | Chromosome 4q25 has been identified as a genomic region associated with gout. However, the associations of gout with the genes in this region have not yet been confirmed. Here, we performed two-stage analysis to determine whether variations in candidate genes in the 4q25 region are associated with gout in a male Chinese Han population. We first evaluated 96 tag single nucleotide polymorphisms (SNPs) in eight inflammatory/immune pathway- or glucose/lipid metabolism-related genes in the 4q25 region in 480 male gout patients and 480 controls. The SNP rs12504538, located in the elongation of very-long-chain-fatty-acid-like family member 6 gene (Elovl6), was found to be associated with gout susceptibility (P(adjusted) = 0.00595). In the second stage of analysis, we performed fine mapping analysis of 93 tag SNPs in Elovl6 and in the epidermal growth factor gene (EGF) and its flanking regions in 1017 male patients gout and 1897 healthy male controls. We observed a significant association between the T allele of EGF rs2298999 and gout (odds ratio = 0.77, 95% confidence interval = 0.67–0.88, P(adjusted) = 6.42 × 10(−3)). These results provide the first evidence for an association between the EGF rs2298999 C/T polymorphism and gout. Our findings should be validated in additional populations. |
format | Online Article Text |
id | pubmed-4978989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49789892016-08-18 Epidermal growth factor gene is a newly identified candidate gene for gout Han, Lin Cao, Chunwei Jia, Zhaotong Liu, Shiguo Liu, Zhen Xin, Ruosai Wang, Can Li, Xinde Ren, Wei Wang, Xuefeng Li, Changgui Sci Rep Article Chromosome 4q25 has been identified as a genomic region associated with gout. However, the associations of gout with the genes in this region have not yet been confirmed. Here, we performed two-stage analysis to determine whether variations in candidate genes in the 4q25 region are associated with gout in a male Chinese Han population. We first evaluated 96 tag single nucleotide polymorphisms (SNPs) in eight inflammatory/immune pathway- or glucose/lipid metabolism-related genes in the 4q25 region in 480 male gout patients and 480 controls. The SNP rs12504538, located in the elongation of very-long-chain-fatty-acid-like family member 6 gene (Elovl6), was found to be associated with gout susceptibility (P(adjusted) = 0.00595). In the second stage of analysis, we performed fine mapping analysis of 93 tag SNPs in Elovl6 and in the epidermal growth factor gene (EGF) and its flanking regions in 1017 male patients gout and 1897 healthy male controls. We observed a significant association between the T allele of EGF rs2298999 and gout (odds ratio = 0.77, 95% confidence interval = 0.67–0.88, P(adjusted) = 6.42 × 10(−3)). These results provide the first evidence for an association between the EGF rs2298999 C/T polymorphism and gout. Our findings should be validated in additional populations. Nature Publishing Group 2016-08-10 /pmc/articles/PMC4978989/ /pubmed/27506295 http://dx.doi.org/10.1038/srep31082 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Han, Lin Cao, Chunwei Jia, Zhaotong Liu, Shiguo Liu, Zhen Xin, Ruosai Wang, Can Li, Xinde Ren, Wei Wang, Xuefeng Li, Changgui Epidermal growth factor gene is a newly identified candidate gene for gout |
title | Epidermal growth factor gene is a newly identified candidate gene for gout |
title_full | Epidermal growth factor gene is a newly identified candidate gene for gout |
title_fullStr | Epidermal growth factor gene is a newly identified candidate gene for gout |
title_full_unstemmed | Epidermal growth factor gene is a newly identified candidate gene for gout |
title_short | Epidermal growth factor gene is a newly identified candidate gene for gout |
title_sort | epidermal growth factor gene is a newly identified candidate gene for gout |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978989/ https://www.ncbi.nlm.nih.gov/pubmed/27506295 http://dx.doi.org/10.1038/srep31082 |
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