Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization

Recent reports have brought back the acetylcholine synthesizing enzyme, choline acetyltransferase in the mainstream research in dementia and the cholinergic anti-inflammatory pathway. Here we report, a specific strategy for the design of novel ChAT ligands based on molecular docking, Hologram Quanti...

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Detalles Bibliográficos
Autores principales: Kumar, Rajnish, Långström, Bengt, Darreh-Shori, Taher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978996/
https://www.ncbi.nlm.nih.gov/pubmed/27507101
http://dx.doi.org/10.1038/srep31247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978996/
https://www.ncbi.nlm.nih.gov/pubmed/27507101
http://dx.doi.org/10.1038/srep31247

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