Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn’s disease and leprosy

Genetic polymorphism within the 9q32 locus is linked with increased risk of several diseases, including Crohn’s disease (CD), primary biliary cholangitis (PBC) and leprosy. The most likely disease-causing gene within 9q32 is TNFSF15, which encodes the pro-inflammatory cytokine TNF super-family membe...

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Detalles Bibliográficos
Autores principales: Sun, Yonghu, Irwanto, Astrid, Toyo-oka, Licht, Hong, Myunghee, Liu, Hong, Andiappan, Anand Kumar, Choi, Hyunchul, Hitomi, Yuki, Yu, Gongqi, Yu, Yongxiang, Bao, Fangfang, Wang, Chuan, Fu, Xian, Yue, Zhenhua, Wang, Honglei, Zhang, Huimin, Kawashima, Minae, Kojima, Kaname, Nagasaki, Masao, Nakamura, Minoru, Yang, Suk-Kyun, Ye, Byong Duk, Denise, Yosua, Rotzschke, Olaf, Song, Kyuyoung, Tokunaga, Katsushi, Zhang, Furen, Liu, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979016/
https://www.ncbi.nlm.nih.gov/pubmed/27507062
http://dx.doi.org/10.1038/srep31429

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