Cargando…
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib has been approved for treatment of advanced ovarian cancer associated with BRCA1 and BRCA2 mutations. BRCA1- and BRCA2-mutated cells, which are homologous recombination (HR) deficient, are hypersensitive to PARPi through the mechanism of...
Autores principales: | Ding, Xia, Chaudhuri, Arnab Ray, Callen, Elsa, Pang, Yan, Biswas, Kajal, Klarmann, Kimberly D., Martin, Betty K., Burkett, Sandra, Cleveland, Linda, Stauffer, Stacey, Sullivan, Teresa, Dewan, Aashish, Marks, Hanna, Tubbs, Anthony T., Wong, Nancy, Buehler, Eugen, Akagi, Keiko, Martin, Scott E., Keller, Jonathan R., Nussenzweig, André, Sharan, Shyam K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979061/ https://www.ncbi.nlm.nih.gov/pubmed/27498558 http://dx.doi.org/10.1038/ncomms12425 |
Ejemplares similares
-
Virus–Host Interactions and the ARTD/PARP Family of Enzymes
por: Kuny, Chad V., et al.
Publicado: (2016) -
PARP10 (ARTD10) modulates mitochondrial function
por: Márton, Judit, et al.
Publicado: (2018) -
Characterization of the DNA dependent activation of human ARTD2/PARP2
por: Obaji, Ezeogo, et al.
Publicado: (2016) -
Structural basis for DNA break recognition by ARTD2/PARP2
por: Obaji, Ezeogo, et al.
Publicado: (2018) -
A Study into the
ADP-Ribosylome of IFN-γ-Stimulated
THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and
ARTD9/PARP9 ADP-Ribosylation
por: Higashi, Hideyuki, et al.
Publicado: (2019)