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Self-organized centripetal movement of corneal epithelium in the absence of external cues

Maintaining the structure of the cornea is essential for high-quality vision. In adult mammals, corneal epithelial cells emanate from stem cells in the limbus, driven by an unknown mechanism towards the centre of the cornea as cohesive clonal groups. Here we use complementary mathematical and biolog...

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Autores principales: Lobo, Erwin P., Delic, Naomi C., Richardson, Alex, Raviraj, Vanisri, Halliday, Gary M., Di Girolamo, Nick, Myerscough, Mary R., Lyons, J. Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979063/
https://www.ncbi.nlm.nih.gov/pubmed/27499113
http://dx.doi.org/10.1038/ncomms12388
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author Lobo, Erwin P.
Delic, Naomi C.
Richardson, Alex
Raviraj, Vanisri
Halliday, Gary M.
Di Girolamo, Nick
Myerscough, Mary R.
Lyons, J. Guy
author_facet Lobo, Erwin P.
Delic, Naomi C.
Richardson, Alex
Raviraj, Vanisri
Halliday, Gary M.
Di Girolamo, Nick
Myerscough, Mary R.
Lyons, J. Guy
author_sort Lobo, Erwin P.
collection PubMed
description Maintaining the structure of the cornea is essential for high-quality vision. In adult mammals, corneal epithelial cells emanate from stem cells in the limbus, driven by an unknown mechanism towards the centre of the cornea as cohesive clonal groups. Here we use complementary mathematical and biological models to show that corneal epithelial cells can self-organize into a cohesive, centripetal growth pattern in the absence of external physiological cues. Three conditions are required: a circumferential location of stem cells, a limited number of cell divisions and mobility in response to population pressure. We have used these complementary models to provide explanations for the increased rate of centripetal migration caused by wounding and the potential for stem cell leakage to account for stable transplants derived from central corneal tissue, despite the predominantly limbal location of stem cells.
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spelling pubmed-49790632016-08-23 Self-organized centripetal movement of corneal epithelium in the absence of external cues Lobo, Erwin P. Delic, Naomi C. Richardson, Alex Raviraj, Vanisri Halliday, Gary M. Di Girolamo, Nick Myerscough, Mary R. Lyons, J. Guy Nat Commun Article Maintaining the structure of the cornea is essential for high-quality vision. In adult mammals, corneal epithelial cells emanate from stem cells in the limbus, driven by an unknown mechanism towards the centre of the cornea as cohesive clonal groups. Here we use complementary mathematical and biological models to show that corneal epithelial cells can self-organize into a cohesive, centripetal growth pattern in the absence of external physiological cues. Three conditions are required: a circumferential location of stem cells, a limited number of cell divisions and mobility in response to population pressure. We have used these complementary models to provide explanations for the increased rate of centripetal migration caused by wounding and the potential for stem cell leakage to account for stable transplants derived from central corneal tissue, despite the predominantly limbal location of stem cells. Nature Publishing Group 2016-08-08 /pmc/articles/PMC4979063/ /pubmed/27499113 http://dx.doi.org/10.1038/ncomms12388 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lobo, Erwin P.
Delic, Naomi C.
Richardson, Alex
Raviraj, Vanisri
Halliday, Gary M.
Di Girolamo, Nick
Myerscough, Mary R.
Lyons, J. Guy
Self-organized centripetal movement of corneal epithelium in the absence of external cues
title Self-organized centripetal movement of corneal epithelium in the absence of external cues
title_full Self-organized centripetal movement of corneal epithelium in the absence of external cues
title_fullStr Self-organized centripetal movement of corneal epithelium in the absence of external cues
title_full_unstemmed Self-organized centripetal movement of corneal epithelium in the absence of external cues
title_short Self-organized centripetal movement of corneal epithelium in the absence of external cues
title_sort self-organized centripetal movement of corneal epithelium in the absence of external cues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979063/
https://www.ncbi.nlm.nih.gov/pubmed/27499113
http://dx.doi.org/10.1038/ncomms12388
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