Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2

MAPK-activated protein kinase 2 (MK2) is a checkpoint kinase involved in the DNA damage response. MK2 inhibition enhances the efficacy of chemotherapeutic agents; however, whether MK2 inhibition alone, without concurrent chemotherapy, would attenuate survival of cancer cells has not been investigate...

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Detalles Bibliográficos
Autores principales: Gurgis, FMS, Åkerfeldt, MC, Heng, B, Wong, C, Adams, S, Guillemin, GJ, Johns, TG, Chircop, M, Munoz, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979411/
https://www.ncbi.nlm.nih.gov/pubmed/27551460
http://dx.doi.org/10.1038/cddiscovery.2015.28

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