The pro-oxidative drug WF-10 inhibits serial killing by primary human cytotoxic T-cells

Cytotoxic T-cells (CTLs) play an important role in many immune-mediated inflammatory diseases. Targeting cytotoxicity of CTLs would allow to interfere with immune-mediated tissue destruction. Here we demonstrate that WF-10, a pro-oxidative compound, inhibits CTL-mediated cytotoxicity. WF-10 did not...

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Detalles Bibliográficos
Autores principales: Wabnitz, G H, Balta, E, Schindler, S, Kirchgessner, H, Jahraus, B, Meuer, S, Samstag, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979520/
https://www.ncbi.nlm.nih.gov/pubmed/27551545
http://dx.doi.org/10.1038/cddiscovery.2016.57

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