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Precambrian origins of the TNFR superfamily

The evolution of the tumor necrosis factor/tumor necrosis factor receptor superfamily (TNF/TNFR) is complicated and not well understood. To date, most TNFR studies have focused on vertebrate models leaving the role of TNFRs in invertebrates largely unexplored. The evolution of important cellular pro...

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Autores principales: Quistad, S D, Traylor-Knowles, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979521/
https://www.ncbi.nlm.nih.gov/pubmed/27551546
http://dx.doi.org/10.1038/cddiscovery.2016.58
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author Quistad, S D
Traylor-Knowles, N
author_facet Quistad, S D
Traylor-Knowles, N
author_sort Quistad, S D
collection PubMed
description The evolution of the tumor necrosis factor/tumor necrosis factor receptor superfamily (TNF/TNFR) is complicated and not well understood. To date, most TNFR studies have focused on vertebrate models leaving the role of TNFRs in invertebrates largely unexplored. The evolution of important cellular processes including stress response, apoptosis, development, and inflammation will be better understood by examining the TNF/TNFR superfamily in ancient invertebrate phyla. How widespread is this gene family within the evolutionary tree of life and is there evidence for similar function in invertebrates? A first step is to identify the presence or absence of these genes within basal metazoan taxa using the signature cysteine-rich domain (CRD) of the TNFR superfamily. In this perspective, we will start by examining what is currently known about the function of TNFRs in invertebrates. Then, we will assess the role of TNFRs in apoptosis and explore the origins of the domains found in TNFRs including the death domain (DD) and CRD. Finally, we will examine the phylogenetic relationship between TNFRs containing DDs identified to date. From these data, we propose a model for a Precambrian origin of TNFRs and their functional role in apoptosis.
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spelling pubmed-49795212016-08-22 Precambrian origins of the TNFR superfamily Quistad, S D Traylor-Knowles, N Cell Death Discov Review Article The evolution of the tumor necrosis factor/tumor necrosis factor receptor superfamily (TNF/TNFR) is complicated and not well understood. To date, most TNFR studies have focused on vertebrate models leaving the role of TNFRs in invertebrates largely unexplored. The evolution of important cellular processes including stress response, apoptosis, development, and inflammation will be better understood by examining the TNF/TNFR superfamily in ancient invertebrate phyla. How widespread is this gene family within the evolutionary tree of life and is there evidence for similar function in invertebrates? A first step is to identify the presence or absence of these genes within basal metazoan taxa using the signature cysteine-rich domain (CRD) of the TNFR superfamily. In this perspective, we will start by examining what is currently known about the function of TNFRs in invertebrates. Then, we will assess the role of TNFRs in apoptosis and explore the origins of the domains found in TNFRs including the death domain (DD) and CRD. Finally, we will examine the phylogenetic relationship between TNFRs containing DDs identified to date. From these data, we propose a model for a Precambrian origin of TNFRs and their functional role in apoptosis. Nature Publishing Group 2016-07-18 /pmc/articles/PMC4979521/ /pubmed/27551546 http://dx.doi.org/10.1038/cddiscovery.2016.58 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Quistad, S D
Traylor-Knowles, N
Precambrian origins of the TNFR superfamily
title Precambrian origins of the TNFR superfamily
title_full Precambrian origins of the TNFR superfamily
title_fullStr Precambrian origins of the TNFR superfamily
title_full_unstemmed Precambrian origins of the TNFR superfamily
title_short Precambrian origins of the TNFR superfamily
title_sort precambrian origins of the tnfr superfamily
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979521/
https://www.ncbi.nlm.nih.gov/pubmed/27551546
http://dx.doi.org/10.1038/cddiscovery.2016.58
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