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Post-translational allosteric activation of the P2X(7) receptor through glycosaminoglycan chains of CD44 proteoglycans

Here, we present evidence for the positive allosteric modulation of the P2X(7) receptor through glycosaminoglycans (GAGs) in CHO (cell line derived from the ovary of the Chinese hamster) cells. The marked potentiation of P2X(7) activity through GAGs in the presence of non-saturating agonists concent...

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Detalles Bibliográficos
Autores principales:	Moura, GEDD, Lucena, SV, Lima, MA, Nascimento, FD, Gesteira, TF, Nader, HB, Paredes-Gamero, EJ, Tersariol, ILS
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979527/ https://www.ncbi.nlm.nih.gov/pubmed/27551441 http://dx.doi.org/10.1038/cddiscovery.2015.5

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