Cargando…

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer

MUC4 is a transmembrane mucin lining the normal colonic epithelium. The aberrant/de novo over-expression of MUC4 is well documented in malignancies of the pancreas, ovary and breast. However, studies have reported the loss of MUC4 expression in the majority of colorectal cancers (CRCs). A MUC4 promo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pai, Priya, Rachagani, Satyanarayana, Dhawan, Punita, Sheinin, Yuri M., Macha, Muzafar A., Qazi, Asif Khurshid, Chugh, Seema, Ponnusamy, Moorthy P., Mallya, Kavita, Pothuraju, Ramesh, Batra, Surinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979589/ https://www.ncbi.nlm.nih.gov/pubmed/27551331 http://dx.doi.org/10.18632/genesandcancer.108

Ejemplares similares

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
por: Vengoji, Raghupathy, et al.
Publicado: (2019)

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism
por: Muniyan, Sakthivel, et al.
Publicado: (2016)

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance
por: Pothuraju, Ramesh, et al.
Publicado: (2020)

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
por: Rachagani, Satyanarayana, et al.
Publicado: (2012)

Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma
por: Vengoji, Raghupathy, et al.
Publicado: (2021)

Nicotine/Cigarette-smoke Promotes Metastasis of Pancreatic Cancer Through α7nAChR-mediated MUC4 Up-regulation
por: Momi, Navneet, et al.
Publicado: (2012)

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2014)

Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2022)

Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer
por: Leon, Frank, et al.
Publicado: (2021)

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells
por: Barkeer, Srikanth, et al.
Publicado: (2018)

Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation
por: Chugh, Seema, et al.
Publicado: (2016)

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model
por: Mallya, Kavita, et al.
Publicado: (2020)

Pathobiological Implications of MUC16 Expression in Pancreatic Cancer
por: Haridas, Dhanya, et al.
Publicado: (2011)

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
por: Lakshmanan, Imayavaramban, et al.
Publicado: (2015)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered Kras(G12D);Pdx1-Cre mouse (KC) model
por: Rachagani, Satyanarayana, et al.
Publicado: (2015)

Gut microbiota: a non-target victim of pesticide-induced toxicity
por: Sharma, Tusha, et al.
Publicado: (2023)

Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions
por: Joshi, Suhasini, et al.
Publicado: (2014)

ST6GalNAc‐I promotes lung cancer metastasis by altering MUC5AC sialylation
por: Lakshmanan, Imayavaramban, et al.
Publicado: (2021)

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy
por: Torres, María P., et al.
Publicado: (2013)

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer
por: Jahan, Rahat, et al.
Publicado: (2019)

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments
por: Das, Srustidhar, et al.
Publicado: (2015)

Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
por: Pothuraju, Ramesh, et al.
Publicado: (2018)

Mucins, gut microbiota, and postbiotics role in colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2021)

Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2020)

MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells
por: Ponnusamy, Moorthy P, et al.
Publicado: (2011)

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer
por: Aithal, Abhijit, et al.
Publicado: (2018)

Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis
por: Barkeer, Srikanth, et al.
Publicado: (2018)

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells
por: Karmakar, Saswati, et al.
Publicado: (2017)

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells
por: Mukhopadhyay, Partha, et al.
Publicado: (2013)

Bowel hath no fury like a gallbladder inflamed
por: Khan, Amad, et al.
Publicado: (2014)

April Hath Put a Spirit of Youth in Everything()
por: Bahn, Geon Ho
Publicado: (2018)

Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades
por: Kunigal, Sateesh, et al.
Publicado: (2012)

Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)
por: Kshirsagar, Prakash G., et al.
Publicado: (2021)

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells
por: Das, Srustidhar, et al.
Publicado: (2015)

“Nature Hath Fram’d Strange Fellows in Her Time”
por: Potter, Polyxeni
Publicado: (2007)

Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model
por: Martinez-Carrasco, Rafael, et al.
Publicado: (2023)

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2019)

Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma
por: Macha, Muzafar A, et al.
Publicado: (2013)

How Soon Hath Time… A History of Two “Seminal” Publications
por: Parker, Geoff A.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hfr713sajhsdvpocd564qui3el