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Combination of JAK2 and HSP90 inhibitors: an effective therapeutic option in drug-resistant chronic myelogenous leukemia

Recent studies suggest that JAK2 serves as a novel therapeutic target in Bcr-Abl+ chronic myelogenous leukemia (CML). We have reported the existence of an HSP90- associated high molecular weight network complex (HMWNC) that is composed of HSP90 client proteins BCR-ABL, JAK2, and STAT3 in wild type B...

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Detalles Bibliográficos
Autores principales:	Chakraborty, Sandip N., Leng, Xiaohong, Perazzona, Bastianella, Sun, Xiaoping, Lin, Yu-Hsi, Arlinghaus, Ralph B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979592/ https://www.ncbi.nlm.nih.gov/pubmed/27551334 http://dx.doi.org/10.18632/genesandcancer.111

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