Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates

This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via (1)H and (13)C NMR spectroscopy. The...

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Autores principales: Dmochowska, Barbara, Sikora, Karol, Woziwodzka, Anna, Piosik, Jacek, Podgórska, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979630/
https://www.ncbi.nlm.nih.gov/pubmed/27559394
http://dx.doi.org/10.3762/bjoc.12.138
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author Dmochowska, Barbara
Sikora, Karol
Woziwodzka, Anna
Piosik, Jacek
Podgórska, Beata
author_facet Dmochowska, Barbara
Sikora, Karol
Woziwodzka, Anna
Piosik, Jacek
Podgórska, Beata
author_sort Dmochowska, Barbara
collection PubMed
description This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via (1)H and (13)C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
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spelling pubmed-49796302016-08-24 Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates Dmochowska, Barbara Sikora, Karol Woziwodzka, Anna Piosik, Jacek Podgórska, Beata Beilstein J Org Chem Full Research Paper This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via (1)H and (13)C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic. Beilstein-Institut 2016-07-12 /pmc/articles/PMC4979630/ /pubmed/27559394 http://dx.doi.org/10.3762/bjoc.12.138 Text en Copyright © 2016, Dmochowska et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Dmochowska, Barbara
Sikora, Karol
Woziwodzka, Anna
Piosik, Jacek
Podgórska, Beata
Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
title Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
title_full Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
title_fullStr Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
title_full_unstemmed Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
title_short Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
title_sort mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979630/
https://www.ncbi.nlm.nih.gov/pubmed/27559394
http://dx.doi.org/10.3762/bjoc.12.138
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AT piosikjacek mutagenicactivityofquaternaryammoniumsaltderivativesofcarbohydrates
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