Cargando…

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell‐Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

An expanded hexanucleotide repeat in a noncoding region of the C9orf72 gene is a major cause of amyotrophic lateral sclerosis (ALS), accounting for up to 40% of familial cases and 7% of sporadic ALS in European populations. We have generated induced pluripotent stem cells (iPSCs) from fibroblasts of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dafinca, Ruxandra, Scaber, Jakub, Ababneh, Nida'a, Lalic, Tatjana, Weir, Gregory, Christian, Helen, Vowles, Jane, Douglas, Andrew G.L., Fletcher‐Jones, Alexandra, Browne, Cathy, Nakanishi, Mahito, Turner, Martin R., Wade‐Martins, Richard, Cowley, Sally A., Talbot, Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979662/ https://www.ncbi.nlm.nih.gov/pubmed/27097283 http://dx.doi.org/10.1002/stem.2388

Ejemplares similares

The Current State of Naïve Human Pluripotency
por: Dodsworth, Benjamin T., et al.
Publicado: (2015)

Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease
por: Jiang, Yan, et al.
Publicado: (2012)

Human Embryonic Stem Cell Lines and Their Use in International Research
por: Löser, Peter, et al.
Publicado: (2010)

A Role for Borg5 During Trophectoderm Differentiation
por: Vong, Queenie P, et al.
Publicado: (2010)

CD30 Expression Reveals that Culture Adaptation of Human Embryonic Stem Cells Can Occur Through Differing Routes
por: Harrison, Neil J, et al.
Publicado: (2009)

Specific Knockdown of OCT4 in Human Embryonic Stem Cells by Inducible Short Hairpin RNA Interference
por: Zafarana, Gaetano, et al.
Publicado: (2009)

Zfp281 Functions as a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells
por: Fidalgo, Miguel, et al.
Publicado: (2011)

Concise Review: Isoforms of OCT4 Contribute to the Confusing Diversity in Stem Cell Biology
por: Wang, Xia, et al.
Publicado: (2010)

Differential Recruitment of Methyl CpG-Binding Domain Factors and DNA Methyltransferases by the Orphan Receptor Germ Cell Nuclear Factor Initiates the Repression and Silencing of Oct4
por: Gu, Peili, et al.
Publicado: (2011)

Breastmilk Is a Novel Source of Stem Cells with Multilineage Differentiation Potential
por: Hassiotou, Foteini, et al.
Publicado: (2012)

The Wnt/β-Catenin Signaling Pathway Tips the Balance Between Apoptosis and Reprograming of Cell Fusion Hybrids
por: Lluis, Frederic, et al.
Publicado: (2010)

Neuronatin Promotes Neural Lineage in ESCs via Ca(2+) Signaling
por: Lin, Hsuan-Hwai, et al.
Publicado: (2010)

Gli1 Is an Inducing Factor in Generating Floor Plate Progenitor Cells from Human Embryonic Stem Cells
por: Denham, Mark, et al.
Publicado: (2010)

Canonical Wnt/β-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression
por: Wagner, Ryan T, et al.
Publicado: (2010)

Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
por: Erceg, Slaven, et al.
Publicado: (2010)

Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions
por: Varas, Florencio, et al.
Publicado: (2009)

Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors
por: Erceg, Slaven, et al.
Publicado: (2009)

Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine
por: Knoepfler, Paul S
Publicado: (2009)

DNA Damage Mediated S and G(2) Checkpoints in Human Embryonal Carcinoma Cells
por: Wang, XiaoQi, et al.
Publicado: (2009)

A Complex Role for FGF-2 in Self-Renewal, Survival, and Adhesion of Human Embryonic Stem Cells
por: Eiselleova, Livia, et al.
Publicado: (2009)

ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation
por: Ougland, Rune, et al.
Publicado: (2012)

Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Allergic Airway Inflammation in Mice
por: Sun, Yue-Qi, et al.
Publicado: (2012)

Hes1 Desynchronizes Differentiation of Pluripotent Cells by Modulating STAT3 Activity
por: Zhou, Xinzhi, et al.
Publicado: (2013)

The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription
por: Renger, Anke, et al.
Publicado: (2013)

Role of MicroRNAs 99b, 181a, and 181b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells
por: Kane, Nicole M, et al.
Publicado: (2012)

Glycogen Synthase Kinase 3β and Activin/Nodal Inhibition in Human Embryonic Stem Cells Induces a Pre-Neuroepithelial State That Is Required for Specification to a Floor Plate Cell Lineage
por: Denham, Mark, et al.
Publicado: (2012)

Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells is Revealed by the ShcD/RaLP Adaptor Protein
por: Turco, Margherita Y, et al.
Publicado: (2012)

Reversible Lineage-Specific Priming of Human Embryonic Stem Cells Can Be Exploited to Optimize the Yield of Differentiated Cells
por: Lee, Jung Bok, et al.
Publicado: (2015)

Single‐Cell XIST Expression in Human Preimplantation Embryos and Newly Reprogrammed Female Induced Pluripotent Stem Cells
por: Briggs, Sharon F., et al.
Publicado: (2015)

Forced Expression of Nanog or Esrrb Preserves the ESC Status in the Absence of Nucleostemin Expression
por: Katano, Miyuki, et al.
Publicado: (2015)

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration
por: Murray, Aoife, et al.
Publicado: (2015)

Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition
por: Speakman, Christopher M., et al.
Publicado: (2014)

MicroRNA‐199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling
por: Chen, Ting, et al.
Publicado: (2015)

IGF‐1 Signaling Plays an Important Role in the Formation of Three‐Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells
por: Mellough, Carla B., et al.
Publicado: (2015)

Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage
por: Simpson, Russell M.L., et al.
Publicado: (2016)

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells
por: Yang, Jian, et al.
Publicado: (2015)

Jun‐Mediated Changes in Cell Adhesion Contribute to Mouse Embryonic Stem Cell Exit from Ground State Pluripotency
por: Veluscek, Giulia, et al.
Publicado: (2016)

CHD1L Regulated PARP1‐Driven Pluripotency and Chromatin Remodeling During the Early‐Stage Cell Reprogramming
por: Jiang, Bo‐Hua, et al.
Publicado: (2015)

Using Zinc Finger Nuclease Technology to Generate CRX‐Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation
por: Collin, Joseph, et al.
Publicado: (2015)

Hhex and Cer1 Mediate the Sox17 Pathway for Cardiac Mesoderm Formation in Embryonic Stem Cells
por: Liu, Yu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dc7s0s1sb5cbai8f036a5l3ep1