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HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study
Controversy exists regarding pathological factors affecting the prognosis of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV-HCC). Their postoperative clinical behaviors and the exact HBV Deoxyribonucleic Acid (DNA) thresholds that distinguish good and poor prognoses are unknown....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979780/ https://www.ncbi.nlm.nih.gov/pubmed/27495026 http://dx.doi.org/10.1097/MD.0000000000004224 |
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author | Li, Zhonghu Zhao, Xin Jiang, Peng Xiao, Senlin Wu, Guo Chen, Kai Zhang, Xi Liu, Hui Han, Xiuguo Wang, Shuguang Li, Xiaowu |
author_facet | Li, Zhonghu Zhao, Xin Jiang, Peng Xiao, Senlin Wu, Guo Chen, Kai Zhang, Xi Liu, Hui Han, Xiuguo Wang, Shuguang Li, Xiaowu |
author_sort | Li, Zhonghu |
collection | PubMed |
description | Controversy exists regarding pathological factors affecting the prognosis of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV-HCC). Their postoperative clinical behaviors and the exact HBV Deoxyribonucleic Acid (DNA) thresholds that distinguish good and poor prognoses are unknown. This study aimed to compare clinicopathological, pre- and postoperative clinical factors and overall and recurrence-free survival (RFS) between HBV-HCC patients and nonhepatitis B and nonhepatitis C HCC (NBC-HCC) patients to determine the optimal prognostic HBV DNA threshold. Data from 1440 patients with HBV-HCC and NBC-HCC who underwent curative hepatectomy were retrospectively analyzed. Liver function in the HBV-HCC group was significantly worse than in the NBC-HCC group. Compared with NBC-HCC patients, HBV-HCC patients had significantly more vascular invasion and advanced HCC. The HBV-HCC patients also had significantly worse liver function and more complications. Further survival analysis showed significantly lower overall and RFS rates and a higher early recurrence rate in the HBV-HCC group. Univariate analysis indicated that HBV was a risk factor for overall and RFS. Finally, X-tile analysis revealed that the optimal HBV DNA cutoff points for predicting RFS and overall survival in HCC patients were 10,100 and 12,800 IU/mL, respectively. After hepatectomy for HCC, HBV-HCC patients had more complications and a worse prognosis than NBC-HCC patients. Antiviral therapy should be considered before hepatectomy in patients with high (more than approximately 10(4) IU/mL) HBV DNA levels. |
format | Online Article Text |
id | pubmed-4979780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49797802016-08-18 HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study Li, Zhonghu Zhao, Xin Jiang, Peng Xiao, Senlin Wu, Guo Chen, Kai Zhang, Xi Liu, Hui Han, Xiuguo Wang, Shuguang Li, Xiaowu Medicine (Baltimore) 5700 Controversy exists regarding pathological factors affecting the prognosis of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV-HCC). Their postoperative clinical behaviors and the exact HBV Deoxyribonucleic Acid (DNA) thresholds that distinguish good and poor prognoses are unknown. This study aimed to compare clinicopathological, pre- and postoperative clinical factors and overall and recurrence-free survival (RFS) between HBV-HCC patients and nonhepatitis B and nonhepatitis C HCC (NBC-HCC) patients to determine the optimal prognostic HBV DNA threshold. Data from 1440 patients with HBV-HCC and NBC-HCC who underwent curative hepatectomy were retrospectively analyzed. Liver function in the HBV-HCC group was significantly worse than in the NBC-HCC group. Compared with NBC-HCC patients, HBV-HCC patients had significantly more vascular invasion and advanced HCC. The HBV-HCC patients also had significantly worse liver function and more complications. Further survival analysis showed significantly lower overall and RFS rates and a higher early recurrence rate in the HBV-HCC group. Univariate analysis indicated that HBV was a risk factor for overall and RFS. Finally, X-tile analysis revealed that the optimal HBV DNA cutoff points for predicting RFS and overall survival in HCC patients were 10,100 and 12,800 IU/mL, respectively. After hepatectomy for HCC, HBV-HCC patients had more complications and a worse prognosis than NBC-HCC patients. Antiviral therapy should be considered before hepatectomy in patients with high (more than approximately 10(4) IU/mL) HBV DNA levels. Wolters Kluwer Health 2016-08-07 /pmc/articles/PMC4979780/ /pubmed/27495026 http://dx.doi.org/10.1097/MD.0000000000004224 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5700 Li, Zhonghu Zhao, Xin Jiang, Peng Xiao, Senlin Wu, Guo Chen, Kai Zhang, Xi Liu, Hui Han, Xiuguo Wang, Shuguang Li, Xiaowu HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study |
title | HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study |
title_full | HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study |
title_fullStr | HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study |
title_full_unstemmed | HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study |
title_short | HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case–control study |
title_sort | hbv is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: a retrospective case–control study |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979780/ https://www.ncbi.nlm.nih.gov/pubmed/27495026 http://dx.doi.org/10.1097/MD.0000000000004224 |
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