Cargando…
Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study
The fatty liver index (FLI), calculated from serum triglyceride, body mass index, waist circumference, and gamma-glutamyltransferase, is considered a surrogate marker of nonalcoholic fatty liver disease (NAFLD). We investigated whether FLI predicts the development of diabetes mellitus (DM) and asses...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979827/ https://www.ncbi.nlm.nih.gov/pubmed/27495073 http://dx.doi.org/10.1097/MD.0000000000004447 |
_version_ | 1782447384177934336 |
---|---|
author | Yadav, Dhananjay Choi, Eunhee Ahn, Song Vogue Koh, Sang Baek Sung, Ki-Chul Kim, Jang-Young Huh, Ji Hye |
author_facet | Yadav, Dhananjay Choi, Eunhee Ahn, Song Vogue Koh, Sang Baek Sung, Ki-Chul Kim, Jang-Young Huh, Ji Hye |
author_sort | Yadav, Dhananjay |
collection | PubMed |
description | The fatty liver index (FLI), calculated from serum triglyceride, body mass index, waist circumference, and gamma-glutamyltransferase, is considered a surrogate marker of nonalcoholic fatty liver disease (NAFLD). We investigated whether FLI predicts the development of diabetes mellitus (DM) and assessed the predictive ability of FLI for new onset of DM in a prospective population-based cohort study. We analyzed a total of 2784 adults (944 men and 1840 women) aged 40 to 70 years without DM at baseline. Participants were classified according to FLI values into 3 groups: FLI < 30, no NAFLD; 30 ≤ FLI ≤ 59, intermediate NAFLD; and FLI ≥ 60, participants with NAFLD. The area under the receiver-operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated to determine whether FLI improved DM risk prediction. During a mean of 2.6 years follow-up, 88 (3.16%) participants developed DM. The odds ratio analyzed from multivariable-adjusted models (95% confidence interval [CI]) for new onset of DM increased in a continuous manner with increased FLI (<30 vs 30–59 vs ≥60 = 1 vs 1.87 [95% CI 1.05–3.33] vs 2.84 [95% CI 1.4–5.75], respectively). The AUC significantly increased when FLI was added to the conventional DM prediction model (0.835, 95% CI: 0.789–0.881, P = 0.0289 vs traditional DM prediction model). The category-free NRI was 0.417 (95% CI: 0.199–0.635) and the IDI was 0.015 (95% CI: 0.003–0.026) for overall study participants. We found that FLI, a surrogate marker of hepatic steatosis, resulted in significant improvement in DM risk prediction. Our finding suggests that FLI may have clinical and prognostic information for incident DM among the Korean adult population. |
format | Online Article Text |
id | pubmed-4979827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49798272016-08-18 Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study Yadav, Dhananjay Choi, Eunhee Ahn, Song Vogue Koh, Sang Baek Sung, Ki-Chul Kim, Jang-Young Huh, Ji Hye Medicine (Baltimore) 4300 The fatty liver index (FLI), calculated from serum triglyceride, body mass index, waist circumference, and gamma-glutamyltransferase, is considered a surrogate marker of nonalcoholic fatty liver disease (NAFLD). We investigated whether FLI predicts the development of diabetes mellitus (DM) and assessed the predictive ability of FLI for new onset of DM in a prospective population-based cohort study. We analyzed a total of 2784 adults (944 men and 1840 women) aged 40 to 70 years without DM at baseline. Participants were classified according to FLI values into 3 groups: FLI < 30, no NAFLD; 30 ≤ FLI ≤ 59, intermediate NAFLD; and FLI ≥ 60, participants with NAFLD. The area under the receiver-operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated to determine whether FLI improved DM risk prediction. During a mean of 2.6 years follow-up, 88 (3.16%) participants developed DM. The odds ratio analyzed from multivariable-adjusted models (95% confidence interval [CI]) for new onset of DM increased in a continuous manner with increased FLI (<30 vs 30–59 vs ≥60 = 1 vs 1.87 [95% CI 1.05–3.33] vs 2.84 [95% CI 1.4–5.75], respectively). The AUC significantly increased when FLI was added to the conventional DM prediction model (0.835, 95% CI: 0.789–0.881, P = 0.0289 vs traditional DM prediction model). The category-free NRI was 0.417 (95% CI: 0.199–0.635) and the IDI was 0.015 (95% CI: 0.003–0.026) for overall study participants. We found that FLI, a surrogate marker of hepatic steatosis, resulted in significant improvement in DM risk prediction. Our finding suggests that FLI may have clinical and prognostic information for incident DM among the Korean adult population. Wolters Kluwer Health 2016-08-07 /pmc/articles/PMC4979827/ /pubmed/27495073 http://dx.doi.org/10.1097/MD.0000000000004447 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 4300 Yadav, Dhananjay Choi, Eunhee Ahn, Song Vogue Koh, Sang Baek Sung, Ki-Chul Kim, Jang-Young Huh, Ji Hye Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study |
title | Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study |
title_full | Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study |
title_fullStr | Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study |
title_full_unstemmed | Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study |
title_short | Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study |
title_sort | fatty liver index as a simple predictor of incident diabetes from the koges-arirang study |
topic | 4300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979827/ https://www.ncbi.nlm.nih.gov/pubmed/27495073 http://dx.doi.org/10.1097/MD.0000000000004447 |
work_keys_str_mv | AT yadavdhananjay fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy AT choieunhee fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy AT ahnsongvogue fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy AT kohsangbaek fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy AT sungkichul fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy AT kimjangyoung fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy AT huhjihye fattyliverindexasasimplepredictorofincidentdiabetesfromthekogesarirangstudy |