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Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute signi...

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Detalles Bibliográficos
Autores principales: Hemmerling, Franziska, Hahn, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979870/
https://www.ncbi.nlm.nih.gov/pubmed/27559404
http://dx.doi.org/10.3762/bjoc.12.148
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author Hemmerling, Franziska
Hahn, Frank
author_facet Hemmerling, Franziska
Hahn, Frank
author_sort Hemmerling, Franziska
collection PubMed
description This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.
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spelling pubmed-49798702016-08-24 Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides Hemmerling, Franziska Hahn, Frank Beilstein J Org Chem Review This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies. Beilstein-Institut 2016-07-20 /pmc/articles/PMC4979870/ /pubmed/27559404 http://dx.doi.org/10.3762/bjoc.12.148 Text en Copyright © 2016, Hemmerling and Hahn https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Hemmerling, Franziska
Hahn, Frank
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
title Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
title_full Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
title_fullStr Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
title_full_unstemmed Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
title_short Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
title_sort biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979870/
https://www.ncbi.nlm.nih.gov/pubmed/27559404
http://dx.doi.org/10.3762/bjoc.12.148
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