Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used...

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Detalles Bibliográficos
Autores principales: Vasilyeva, Svetlana V, Filichev, Vyacheslav V, Boutorine, Alexandre S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979877/
https://www.ncbi.nlm.nih.gov/pubmed/27559384
http://dx.doi.org/10.3762/bjoc.12.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979877/
https://www.ncbi.nlm.nih.gov/pubmed/27559384
http://dx.doi.org/10.3762/bjoc.12.128

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