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Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used...

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Detalles Bibliográficos
Autores principales:	Vasilyeva, Svetlana V, Filichev, Vyacheslav V, Boutorine, Alexandre S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2016
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979877/ https://www.ncbi.nlm.nih.gov/pubmed/27559384 http://dx.doi.org/10.3762/bjoc.12.128

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