Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries

We explore here the potential of a newly described technology, which is named PROFILER and is based on next generation sequencing of gene-specific lambda phage-displayed libraries, to rapidly and accurately map monoclonal antibody (mAb) epitopes. For this purpose, we used a novel mAb (designated 31E...

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Detalles Bibliográficos
Autores principales: Domina, Maria, Lanza Cariccio, Veronica, Benfatto, Salvatore, Venza, Mario, Venza, Isabella, Donnarumma, Danilo, Bartolini, Erika, Borgogni, Erica, Bruttini, Marco, Santini, Laura, Midiri, Angelina, Galbo, Roberta, Romeo, Letizia, Patanè, Francesco, Biondo, Carmelo, Norais, Nathalie, Masignani, Vega, Teti, Giuseppe, Felici, Franco, Beninati, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980009/
https://www.ncbi.nlm.nih.gov/pubmed/27508302
http://dx.doi.org/10.1371/journal.pone.0160702

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