Cargando…

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases

We performed a Phenome-Wide Association Study (PheWAS) to identify interrelationships between the immune system genetic architecture and a wide array of phenotypes from two de-identified electronic health record (EHR) biorepositories. We selected variants within genes encoding critical factors in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verma, Anurag, Basile, Anna O., Bradford, Yuki, Kuivaniemi, Helena, Tromp, Gerard, Carey, David, Gerhard, Glenn S., Crowe, James E., Ritchie, Marylyn D., Pendergrass, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980020/ https://www.ncbi.nlm.nih.gov/pubmed/27508393 http://dx.doi.org/10.1371/journal.pone.0160573

Ejemplares similares

A simulation study investigating power estimates in phenome-wide association studies
por: Verma, Anurag, et al.
Publicado: (2018)

eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants
por: Verma, Anurag, et al.
Publicado: (2016)

Rare variants in drug target genes contributing to complex diseases, phenome-wide
por: Verma, Shefali Setia, et al.
Publicado: (2018)

Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View
por: Pendergrass, Sarah A, et al.
Publicado: (2012)

Author Correction: Rare variants in drug target genes contributing to complex diseases, phenome-wide
por: Verma, Shefali Setia, et al.
Publicado: (2018)

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols
por: Moore, Carrie B., et al.
Publicado: (2014)

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry
por: Dumitrescu, Logan, et al.
Publicado: (2015)

Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk loci
por: Moon, Chang Yoon, et al.
Publicado: (2021)

Imputation and quality control steps for combining multiple genome-wide datasets
por: Verma, Shefali S., et al.
Publicado: (2014)

Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202
por: Verma, Anurag, et al.
Publicado: (2017)

Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies
por: Li, Binglan, et al.
Publicado: (2019)

Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
por: Hall, Molly A., et al.
Publicado: (2014)

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index
por: Cronin, Robert M., et al.
Publicado: (2014)

A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains
por: Avery, Christy L., et al.
Publicado: (2011)

Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits
por: Choe, Eun Kyung, et al.
Publicado: (2022)

The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research
por: Ritchie, Marylyn D., et al.
Publicado: (2015)

Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies
por: Mitchell, Sabrina L, et al.
Publicado: (2014)

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations
por: Denny, Joshua C., et al.
Publicado: (2010)

Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records
por: Crosslin, David R., et al.
Publicado: (2014)

Molecular basis and genetic predisposition to intracranial aneurysm
por: Tromp, Gerard, et al.
Publicado: (2014)

Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression()
por: Li, Binglan, et al.
Publicado: (2018)

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans
por: Pendergrass, Sarah A., et al.
Publicado: (2019)

Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico
por: Zhang, Xinyuan, et al.
Publicado: (2019)

42855 A Phenomics Approach to the Categorization and Refinement of Heart Failure
por: Reza, Nosheen, et al.
Publicado: (2021)

PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies
por: Hall, Molly A., et al.
Publicado: (2017)

Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes
por: Lee, Chia-Jung, et al.
Publicado: (2022)

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR
por: Safarova, Maya S., et al.
Publicado: (2019)

Another Round of “Clue” to Uncover the Mystery of Complex Traits
por: Verma, Shefali Setia, et al.
Publicado: (2018)

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits
por: Park, Joshua K, et al.
Publicado: (2023)

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations
por: Simba, Hannah, et al.
Publicado: (2019)

Editorial: FDA-Approved Drug Repositioning for P-Glycoprotein Overexpressing Resistant Cancer
por: Yoon, Sungpil, et al.
Publicado: (2021)

Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
por: Bellomo, Tiffany R., et al.
Publicado: (2022)

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults
por: Li, Binglan, et al.
Publicado: (2021)

Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes
por: Wendt, Frank R., et al.
Publicado: (2022)

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
por: Pendergrass, Sarah A., et al.
Publicado: (2013)

ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci
por: Turner, Stephen D, et al.
Publicado: (2010)

Population risk factor estimates for abdominal aortic aneurysm from electronic medical records: a case control study
por: Smelser, Diane T, et al.
Publicado: (2014)

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
por: Bone, William P., et al.
Publicado: (2021)

High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus
por: Wang, Xiaoju, et al.
Publicado: (2002)

Environmental and life-style risk factors for esophageal squamous cell carcinoma in Africa: a systematic review and meta-analysis
por: Simba, Hannah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ueho0rpbnbkngsluppd2t5q7ru