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IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA

Oncogenic activation of Ras/MEK downregulates the expression of interferon regulatory factor 1 (IRF1), which is a prerequisite for oncolytic viruses to replicate in cancer cells [1]. Moreover, restoration of IRF1 expression is essential to induce apoptosis of cancer cells treated with a MEK inhibito...

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Detalles Bibliográficos
Autores principales:	Komatsu, Yumiko, Derwish, Leena, Hirasawa, Kensuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980046/ https://www.ncbi.nlm.nih.gov/pubmed/27508303 http://dx.doi.org/10.1371/journal.pone.0160529

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