Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

Elevated blood CXCL10/IP-10 levels during primary HIV-1 infection (PHI) were described as an independent marker of rapid disease onset, more robust than peak viremia or CD4 cell nadir. IP-10 enhances the recruitment of CXCR3+ cells, which include major HIV-target cells, raising the question if it pr...

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Detalles Bibliográficos
Autores principales: Ploquin, Mickaël J., Madec, Yoann, Casrouge, Armanda, Huot, Nicolas, Passaes, Caroline, Lécuroux, Camille, Essat, Asma, Boufassa, Faroudy, Jacquelin, Béatrice, Jochems, Simon P., Petitjean, Gaël, Angin, Mathieu, Gärtner, Kathleen, Garcia-Tellez, Thalía, Noël, Nicolas, Booiman, Thijs, Boeser-Nunnink, Brigitte D., Roques, Pierre, Saez-Cirion, Asier, Vaslin, Bruno, Dereudre-Bosquet, Nathalie, Barré-Sinoussi, Françoise, Ghislain, Mathilde, Rouzioux, Christine, Lambotte, Olivier, Albert, Matthew L., Goujard, Cécile, Kootstra, Neeltje, Meyer, Laurence, Müller-Trutwin, Michaela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980058/
https://www.ncbi.nlm.nih.gov/pubmed/27509048
http://dx.doi.org/10.1371/journal.ppat.1005774

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