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Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

RATIONALE: Therapeutic agents for memory enhancement in psychiatric disorders, such as schizophrenia, are urgently needed. OBJECTIVE: The aim of this study is to characterize the preclinical profile of ITI-214, a potent inhibitor of phosphodiesterase 1 (PDE1). METHODS: ITI-214 was assayed for inhibi...

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Detalles Bibliográficos
Autores principales:	Snyder, Gretchen L., Prickaerts, Jos, Wadenberg, Marie-Louise, Zhang, Lei, Zheng, Hailin, Yao, Wei, Akkerman, Sven, Zhu, Hongwen, Hendrick, Joseph P., Vanover, Kimberly E., Davis, Robert, Li, Peng, Mates, Sharon, Wennogle, Lawrence P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980415/ https://www.ncbi.nlm.nih.gov/pubmed/27342643 http://dx.doi.org/10.1007/s00213-016-4346-2

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