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Primary female breast sarcoma: clinicopathological features, treatment and prognosis

Primary breast sarcoma (PBS) is a rare and heterogeneous group of malignancies with limited publications. We obtained data from the Surveillance, Epidemiology, and End Results Program and performed analysis to determine clinicopathological characteristics of PBS and estimate their associations with...

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Autores principales: Yin, Ming, Mackley, Heath B., Drabick, Joseph J., Harvey, Harold A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980597/
https://www.ncbi.nlm.nih.gov/pubmed/27510467
http://dx.doi.org/10.1038/srep31497
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author Yin, Ming
Mackley, Heath B.
Drabick, Joseph J.
Harvey, Harold A.
author_facet Yin, Ming
Mackley, Heath B.
Drabick, Joseph J.
Harvey, Harold A.
author_sort Yin, Ming
collection PubMed
description Primary breast sarcoma (PBS) is a rare and heterogeneous group of malignancies with limited publications. We obtained data from the Surveillance, Epidemiology, and End Results Program and performed analysis to determine clinicopathological characteristics of PBS and estimate their associations with overall survival (OS) and cancer-specific survival (CSS). Median age of PBS was 55–59 years and median OS was 108 months. Age, overlap or entire breast involvement, tumor histology, and tumor spread were associated with poor survival outcomes. In the multivariable analysis, tumor size, lymph node involvement, distant metastasis and histologic grade were correlated with survival outcomes (P < 0.001). In M0 patients, mastectomy was associated with worse survival outcomes compared with breast conservative surgery (BCS) (adjusted hazard ratio [adjHR], 1.80; 95% CI, 1.31–2.47), regardless of tumor size, tumor grade, tumor histology or radiation history. Adjuvant radiation improved survival outcomes in patients with tumor size >5 cm (adjHR, 0.63; 95% CI, 0.43–0.91), but not in patients with tumor size ≤ 5 cm. Our study demonstrated clinicopathological characteristics of PBS in the US population and supports performing BCS if R0 resection can be achieved, with radiation if tumor size is over 5 cm.
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spelling pubmed-49805972016-08-19 Primary female breast sarcoma: clinicopathological features, treatment and prognosis Yin, Ming Mackley, Heath B. Drabick, Joseph J. Harvey, Harold A. Sci Rep Article Primary breast sarcoma (PBS) is a rare and heterogeneous group of malignancies with limited publications. We obtained data from the Surveillance, Epidemiology, and End Results Program and performed analysis to determine clinicopathological characteristics of PBS and estimate their associations with overall survival (OS) and cancer-specific survival (CSS). Median age of PBS was 55–59 years and median OS was 108 months. Age, overlap or entire breast involvement, tumor histology, and tumor spread were associated with poor survival outcomes. In the multivariable analysis, tumor size, lymph node involvement, distant metastasis and histologic grade were correlated with survival outcomes (P < 0.001). In M0 patients, mastectomy was associated with worse survival outcomes compared with breast conservative surgery (BCS) (adjusted hazard ratio [adjHR], 1.80; 95% CI, 1.31–2.47), regardless of tumor size, tumor grade, tumor histology or radiation history. Adjuvant radiation improved survival outcomes in patients with tumor size >5 cm (adjHR, 0.63; 95% CI, 0.43–0.91), but not in patients with tumor size ≤ 5 cm. Our study demonstrated clinicopathological characteristics of PBS in the US population and supports performing BCS if R0 resection can be achieved, with radiation if tumor size is over 5 cm. Nature Publishing Group 2016-08-11 /pmc/articles/PMC4980597/ /pubmed/27510467 http://dx.doi.org/10.1038/srep31497 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yin, Ming
Mackley, Heath B.
Drabick, Joseph J.
Harvey, Harold A.
Primary female breast sarcoma: clinicopathological features, treatment and prognosis
title Primary female breast sarcoma: clinicopathological features, treatment and prognosis
title_full Primary female breast sarcoma: clinicopathological features, treatment and prognosis
title_fullStr Primary female breast sarcoma: clinicopathological features, treatment and prognosis
title_full_unstemmed Primary female breast sarcoma: clinicopathological features, treatment and prognosis
title_short Primary female breast sarcoma: clinicopathological features, treatment and prognosis
title_sort primary female breast sarcoma: clinicopathological features, treatment and prognosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980597/
https://www.ncbi.nlm.nih.gov/pubmed/27510467
http://dx.doi.org/10.1038/srep31497
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