Enzyme overexpression – an exercise toward understanding regulation of heparan sulfate biosynthesis

Biosynthesis of heparan sulfate (HS) involves conversion of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) units catalyzed by glucuronyl C5-epimerase (Hsepi). IdoA units are the favored substrate for 2-O-sulfotransferase (2OST). We used HEK293 cells as a model to investigate the effects of overe...

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Detalles Bibliográficos
Autores principales: Fang, Jianping, Song, Tianyi, Lindahl, Ulf, Li, Jin-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980632/
https://www.ncbi.nlm.nih.gov/pubmed/27511124
http://dx.doi.org/10.1038/srep31242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980632/
https://www.ncbi.nlm.nih.gov/pubmed/27511124
http://dx.doi.org/10.1038/srep31242

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